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Retinoic acid maintains olfactory progenitor cells during neurogenesis and regeneration
Author(s) -
Marie Paschaki,
Yuko Muta,
Yoko Matsuoka,
Siu-Shan Mak,
Laura Cammas,
Pascal Dolle,
Raj Ladher,
Alessio Delogu,
Katherine Sellers,
David Sugden,
John,
Rubenstein,
Thomas Jessell,
Andrew Lumsden
Publication year - 2012
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2012.03.294
Subject(s) - neurogenesis , retinoic acid , progenitor cell , regeneration (biology) , neuroscience , progenitor , biology , stem cell , microbiology and biotechnology , genetics , gene
In order to fulfil its chemosensory role, olfactory neurons must extend their dendrites into the external environment. This contact makes them prone to damage. However, function is maintained throughout life due to a series of progenitors present in the olfactory epithelium that are capable of replacing and replenishing damaged olfactory neurons. This makes the olfactory epithelium one of the few regenerating neuronal populations in adult mammals. However the mechanisms that control regeneration are not well characterized. We show that retinoic acid (RA) promotes Pax6 positive olfactory basal cells, and prevents their progression into committed neuronal precursors. RA depletion results in a failure of progenitor maintenance and consequently, due to progenitor depletion, differentiation is not sustained. Furthermore, the regenerative capacity of olfactory epithelium from mice mutant for retinaldehyde dehydrogenase 3 (raldh3) is impaired. Our data suggest a mechanism by which local modulation of RA may trigger olfactory repair and renewal in adults.