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Presenilin 2 is involved in apoptosis during development of mouse cerebral cortex
Author(s) -
K. Ghosal,
A. Surolia,
M. K. Thakur,
E.,
Coppola,
M.-R.,
Hirsch,
C.,
Birchmeier,
C. Goridis,
J.-F. Brunet
Publication year - 2012
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2012.03.280
Subject(s) - presenilin , citation , neuroscience , cerebral cortex , library science , cognitive science , psychology , computer science , medicine , pathology , alzheimer's disease , disease
were crucial genes that were upregulated upon neural differentiation in stem cells derived from rat as well as in neuronal cell lines. Furthermore overexpression of SOCS3 in neuronal stem cells exhibited increased primary neurite number as well as neurite length and in PC12 cells, neurite outgrowth was induced under nondifferentiating conditions. SOCS3 expression also up-regulated expression of GAP43, a neuronal marker associated with neurite outgrowth. Incidentally erk was downregulated upon SOCS3 expression, indicating intricate signaling mechanisms leading to neuronal cell differentiation. This data was further confirmed by the SOCS3 knockdown studies. In conclusion ours results indicating that these SOCS3 molecules are involved in the differentiation of neural cells, which would be potentially useful in future therapies aimed at reducing the growth of some cancers by making them less sensitive to certain growth factors on the one hand, and to increase cell survival in neurodegenerative disorders on the other hand.