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Functional genetic polymorphisms in SIM2 and ETS2: Role in Down syndrome
Author(s) -
Samikshan Dutta,
Swagata Sinha,
Das Bhowmik,
S. Chaudhury,
S. Dutta,
A. Chatterjee,
A.,
Choudhury,
G. Mahapatra
Publication year - 2012
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2012.03.275
Subject(s) - citation , genetics , political science , psychology , library science , computer science , biology
We have used social defeat model to induce depression like phenotype in C57bl/6 mice by subjecting them to CD1 aggressors and investigated the changes in epigenetic regulators associated with DNA methylation and histone lysine methylation/demethylation. Interestingly, few of the epigenetic regulators acting on histone H3 lysine 4,9,27 appeared to be affected significantly in neurogenic SGZ, following repeated defeat stress. One of the methyl binding domain protein also appeared to be affected in SGZ. Studies are underway to uncover the cross-talk between regulators of DNA methylation and H3 repressive methylation. We have also found few of the jumonji domain containing HKDMs significantly altered in neurogenic niche. Neural stem or progenitor cells from both unstressed control and defeated or depressed mice brain are being studied ex vivo and the role of these chromatin or epigenetic regulators on their proliferation, differentiation and cell fate are explored now.