Role of axonal transport in regeneration of mechanosensory neurons in  C. elegans | Zendy

Seema  Sheoran | Zendy; Sucheta  Kulkarni | Zendy; Sandhya P. Koushika | Zendy

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Role of axonal transport in regeneration of mechanosensory neurons in C. elegans

Author(s) -

Seema Sheoran,

Sucheta Kulkarni,

Sandhya P. Koushika

Publication year - 2012

Publication title -

international journal of developmental neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.761

H-Index - 88

eISSN - 1873-474X

pISSN - 0736-5748

DOI - 10.1016/j.ijdevneu.2012.03.258

Subject(s) - regeneration (biology) , neuroscience , biology , microbiology and biotechnology

embryonic stem cells. For a successful transplantation, sufficient percentage of photoreceptors is to be generated in vitro. Our approach to address this problem is to activate photoreceptor development and differentiation from the ES cells/neural stem cells/precursors (mouse PN1 retinal cells) in vivo by manipulating intrinsic as well as extrinsic factors. MicroRNAs are important in vivo regulators. The stage-specific or preferentially expressed miRNAs may play unique roles in the fine-tuning of spatial and temporal sequences in retinal development.

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