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Role of axonal transport in regeneration of mechanosensory neurons in C. elegans
Author(s) -
Seema Sheoran,
Sucheta Kulkarni,
Sandhya P. Koushika
Publication year - 2012
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2012.03.258
Subject(s) - regeneration (biology) , neuroscience , biology , microbiology and biotechnology
embryonic stem cells. For a successful transplantation, sufficient percentage of photoreceptors is to be generated in vitro. Our approach to address this problem is to activate photoreceptor development and differentiation from the ES cells/neural stem cells/precursors (mouse PN1 retinal cells) in vivo by manipulating intrinsic as well as extrinsic factors. MicroRNAs are important in vivo regulators. The stage-specific or preferentially expressed miRNAs may play unique roles in the fine-tuning of spatial and temporal sequences in retinal development.