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REMS deprivation decreases expression of voltage gated sodium channels in dorsal raphe neurons in rats
Author(s) -
Anurag Sharma,
Abhishek Sahasrabudhe,
N. V. Giridharan,
M. Raghunath
Publication year - 2012
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2012.03.251
Subject(s) - dorsal raphe nucleus , neuroscience , dorsum , raphe nuclei , sodium channel , citation , psychology , chemistry , biology , medicine , computer science , sodium , library science , anatomy , serotonin , receptor , organic chemistry , serotonergic
prevented B[a]P-induced intracellular increase in Ca2+ both in C6 and Neuro2a. Conclusion: B[a]P inhibited learning and memory possibly by increasing NR1and NR2B-receptors. NA appears to have a protective role, possibly by inhibiting intracellular Ca2+-level. Acute and chronic effects of NA may differ and may be of clinical significance, which need to be studied. Acknowledgements: Funding to MP under WOS’A’/DST and to BNM under JC Bose Fellowship.