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Noradrenaline deficiency in brain may facilitate progression of Alzheimer's disease
Author(s) -
S. Singh,
S. S. Komath,
B. N. Mallick,
A. Singh
Publication year - 2012
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2012.03.246
Subject(s) - citation , disease , neuroscience , psychology , gerontology , medicine , library science , computer science , pathology
prevented if orexinergic receptor1 antagonist was simultaneously microinjected into the LC along with glutamate microinjection into the Pef. Control studies were performed by saline injection. The findings confirm that the effect of activation of Peforexinergic neurons is routed through the LC. Since REMS-duration and not its frequency was affected it is likely that orexin is involved in maintenance of REMS. The findings in vivo help understanding the neural regulation of REMS in normal and altered states. Acknowledgements: Funding from CSIR and DBT.