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Superparamagnetic nanoparticles implantation and magnetic field exposure facilitates neuroregeneration and functional recovery in spinal cord transected rats
Author(s) -
Ajinkya Deogade,
Arghya Mukherjee,
Nishikant Subhedar,
Aurnab Ghose
Publication year - 2012
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2012.03.229
Subject(s) - neuroregeneration , spinal cord injury , spinal cord , neuroscience , medicine , psychology , central nervous system
Neuropeptide Y (NPY) has been implicated as a neuromodulator mediating a number of physiological functions including anxiety, processing of gustatory information and energy homeostasis. We find that a subset of olfactory sensory neurons (OSNs) in zebrafish express NPY from early development through adulthood. Co-localization studies with OSN type markers suggest that NPY is limited to ciliated OSNs. These NPY-positive OSNs terminate in discrete glomeruli in the olfactory bulb and co-localize with the synaptic vesicle protein SV2. With a view to interrogate the functional role of NPY in olfaction, we have developed an aversive olfactory assay in zebrafish larvae. Larvae treated with a small molecule NPY receptor antagonist fail to respond to aversive olfactory signals. Our data implicates for the first time and a direct function for NPY in olfaction.