A microcontact printing based assay to investigate the physiological functions of axonal mechanical tension | Zendy

Ajinkya  Deogade | Zendy; Arghya  Mukherjee | Zendy

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A microcontact printing based assay to investigate the physiological functions of axonal mechanical tension

Author(s) -

Ajinkya Deogade,

Arghya Mukherjee

Publication year - 2012

Publication title -

international journal of developmental neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.761

H-Index - 88

eISSN - 1873-474X

pISSN - 0736-5748

DOI - 10.1016/j.ijdevneu.2012.03.228

Subject(s) - microcontact printing , citation , computer science , tension (geology) , neuroscience , information retrieval , world wide web , nanotechnology , psychology , materials science , composite material , ultimate tensile strength

Neuropeptide Y (NPY) has been implicated as a neuromodulator mediating a number of physiological functions including anxiety, processing of gustatory information and energy homeostasis. We find that a subset of olfactory sensory neurons (OSNs) in zebrafish express NPY from early development through adulthood. Co-localization studies with OSN type markers suggest that NPY is limited to ciliated OSNs. These NPY-positive OSNs terminate in discrete glomeruli in the olfactory bulb and co-localize with the synaptic vesicle protein SV2. With a view to interrogate the functional role of NPY in olfaction, we have developed an aversive olfactory assay in zebrafish larvae. Larvae treated with a small molecule NPY receptor antagonist fail to respond to aversive olfactory signals. Our data implicates for the first time and a direct function for NPY in olfaction.

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