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Combined diffusion‐ and perfusion‐weighted imaging: a new way for the assessment of hemispheric transient ischemic attack patients
Author(s) -
Tong Tong,
Zhenwei Yao,
Xiaoyuan Feng
Publication year - 2011
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2010.09.002
Subject(s) - medicine , magnetic resonance imaging , perfusion , cardiology , diffusion mri , perfusion scanning , stroke (engine) , white matter , cerebral blood flow , diffusion weighted magnetic resonance imaging , ischemia , radiology , mechanical engineering , engineering
Abnormalities in diffusion‐weighted and perfusion‐weighted magnetic resonance images not only occur in stroke patients but also in transient ischemic attack patients. We found magnetic resonance images were abnormal in 28 patients (68%): 15 had diffusion‐weighted imaging abnormalities, 7 had both diffusion‐weighted imaging and perfusion‐weighted imaging defects and 6 had an isolated perfusion‐weighted imaging abnormality. Patients with shorter onset to magnetic resonance imaging, large artery atherothrombosis, coronary artery disease, hyperlipidemia and hemiparesis were more likely to show perfusion‐weighted imaging abnormalities. Compared with patients who had a good prognosis, in poor prognosis patients, the relative cerebral blood flow and relative cerebral blood volume was significantly higher. The data suggest that transient ischemic attack patients are more likely to have a poor prognosis when white matter of the symptomatic side shows hyperperfusion within 24 h of symptom onset; however, patients are more likely to have a good prognosis when white matter of the symptomatic side shows hypoperfusion.