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Nerve growth factor, birth outcome and pre‐eclampsia
Author(s) -
Kilari Anitha,
Mehendale Savita,
Pisal Hemlata,
Panchanadikar Tushar,
Kale Anvita,
Joshi Sadhana
Publication year - 2011
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2010.09.001
Subject(s) - eclampsia , outcome (game theory) , nerve growth factor , obstetrics , pregnancy , medicine , biology , economics , receptor , genetics , mathematical economics
Abstract The present study compares nerve growth factor (NGF) levels between preeclamptic (PE) ( n = 86) and normotensive (NT) women ( n = 105) and their associations with blood pressure and infant size. Maternal plasma NGF levels were reduced ( p < 0.05) in the PE group as compared to the NT group. Furthermore, NGF levels were reduced in PE mothers delivering low birth weight babies (LBW) as compared to NT mothers delivering LBW babies. Maternal NGF levels were negatively ( p = 0.029) associated with blood pressure in preeclamptic mothers. Cord NGF levels were negatively associated ( p = 0.026) with birth weight in the normotensive group. NGF levels are differently regulated in preeclamptic and normotensive mothers delivering LBW babies. Future studies need to investigate mechanisms underlying this pathophysiology and follow‐up of these babies to better understand the role of NGF in brain development in later life.