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[P2.70]: Relation between child abuse and/or neglect and hippocampal volumes, and cortical thickness, in first episode psychosis patients
Author(s) -
Charil A.,
Lepage M.,
Czechowska Y.,
Joober R.,
Laplante D.P.,
King S.
Publication year - 2010
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2010.07.200
Subject(s) - mental health , neglect , library science , psychology , psychiatry , gerontology , medicine , computer science
AP2 as linker for clathrin to the endocytic membrane. We find that knock-down of the subunit AP2m1 by an antisense-morpholino based approach leads to a down-regulation of otx2 expression as well as an up-regulation of wnt/ -catenin target gene expression such as lef1. These data suggest an increase in wnt/ -catenin signalling possibly by an expansion of the efficiency range. In vivo imaging of the endocytic process of wnt8-GFP at early gastrulation stage, however, does not reveal any differences of the Wnt8 uptake-rate in responding cells judged by quantification of confocal images. Therefore we are presently testing other possibilities of an AP2m1 mediated regulation of the wnt/ -catenin signaling pathway.