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[P2.69]: The clathrin adaptor‐protein subunit ap2m1 regulates canonical Wnt signalling in early neural development of the zebrafish
Author(s) -
Hagemann A.I.,
Schindler S.,
Scholpp S.
Publication year - 2010
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2010.07.199
Subject(s) - citation , wnt signaling pathway , library science , zebrafish , computer science , biology , genetics , gene
inal Nucleus (MTN). Analyzes of OC mutant fetuses at e9.5 indicated that the MTN was lost in the absence of OC factors. Therefore, we hypothesize a non cell-autonomous role of the OC factors in LC development: proper development of the MTN would be essential for the maintenance of the LC, potentially via BDNF secretion. A hindbrain slice culture model has been developed to test this hypothesis. These results indicate that the OC factors are essential regulators of the development of catecholaminergic populations and suggest the existence of a molecular crosstalk between the MTN and the LC during development.