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[P2.65]: First genome‐wide association study in Asian population in autism spectrum disorder
Author(s) -
Cho I.H.,
Yoo H.J.,
Kim S.A.,
Park M.,
Cho S.C.,
Park T.W.
Publication year - 2010
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2010.07.195
Subject(s) - national park , library science , geography , the republic , population , political science , demography , sociology , archaeology , philosophy , theology , computer science
Our results suggest that the inhibition of Na+, K+-ATPase as well as the impairment on the glutamate uptake promoted by hyperhomocysteinemia in the hippocampus of young rats, is probably mediated by oxidative stress, since the treatment with antioxidant vitamin C prevented such effects. These findings may be, at least in part, responsible by the mechanisms related to the brain damage observed in hyperhomocysteinemic patients. Supported by CNPq (Brazil).