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[P2.34]: The three hit hypothesis of schizophrenia tested in genetically selected rats exposed to early life experience and adolescent psycho‐social stressor
Author(s) -
Daskalakis N.P.,
Fung W.L.,
Schnorr S.,
Meelis W.,
Oitzl M.S.,
Kloet E.R.
Publication year - 2010
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2010.07.164
Subject(s) - psychology , philosophy , theology
IGF-1R blocking antibody. Consistent with the shRNA study results, the colonies were reduced in size, but the number of colonies produced was unaffected. Additionally, we repeated this experiment with an analog to IGF2 that does not bind IGF-2R and obtained similar results. Altogether we conclude that the IGF-1R regulates NSP cell proliferation whereas self-renewal and maintenance are promoted by IGF2 independent of IGF-1R or IGF-2R. Supported by a Dean’s Grant from NJMS awarded to SWL and F31NS065607 awarded to ANZ.