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[P2.32]: IGF2 promotes murine neural stem/progenitor cell self‐renewal independent of IGF‐1R and IGF‐2R
Author(s) -
Ziegler A.N.,
Rowzee A.M.,
Forbes B.,
Wood T.L.,
Levison S.W.
Publication year - 2010
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2010.07.162
Subject(s) - neural stem cell , progenitor cell , progenitor , stem cell , microbiology and biotechnology , biology , neuroscience
with respect to the aetiology that describes the pathogenesis of these disorders (López Gómez et al., 2008). Thus, a range of explanations from a neurogenetic perspective has appeared and various combinations of the genes involved have been presented. Also, the configuration of the brain architecture has been focus or attention, giving rise to several theories: theory of mind, dysfunctional system of mirror neurons, neurofunctional and executive alterations. The presence of neurochemical and metabolic alterations, various viruses, bacteria and /or teratogenic substances has been investigated, together with studies on environmental contamination with potential fetal/neonatal effects. The presence of various maternal perigestationals risks, for instance, Rh incompatibility, vaginal bleeding, dystocic labor, among others, have also been the centre of attention (López Gómez et al., 2008; López Gómez et al., 2009). However, all of them have been, so far, only a vague and not very fruitful approach, since none of them can, by itself, explain the aetiology of PDDs. The aim of this study was to investigate whether there are differences between tobacco use and alcohol consumption during pregnancy in a sample of mothers whose children were diagnosed with PDDs (N = 94) compared with a control group (N = 165). The sample comprised 68 children with autistic disorder, 6 with Asperger’s syndrome, 1 with Rett disorder and 19 with PDD-NOS. The results showed that there are not significant differences among those groups. Therefore, one might conclude that, according to the results found in this study, there are not significant differences between the experimental and the control groups and, therefore, the use of tobacco and the consumption of alcohol during pregnancy cannot not be related to the aetiology of the PDDs. References: