[P2.18]: Neural development features: Spatio‐temporal development of C. elegans neuronal network

day 30 (P30), with erratic breathing, frequent apnoeas, and fatal respiratory distress at around P60 (Viemari et al, 2005). The breathing symptoms of Mecp2-/y mice are caused by earlier deficits of several neurochemical systems (Katz et al, 2009). GABA deficits which appear as early as P7 (Medhiran et al, 2008), may have a primary role in the breathing symptoms. Revisiting the breathing phenotype of young Mecp2-/y mice and analyzing the effects on breathing symptoms of midazolam, a benzodiazepine of clinical use known to potentiate the effects of endogenous GABA. Plethysmography in conscious Mecp2-/y mice was used to record breathing and analyse the changes induced by single i.p. applications of midazolam. In Mecp2-/y mice, we show that: