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[P2.18]: Neural development features: Spatio‐temporal development of C. elegans neuronal network
Author(s) -
Varier S.,
Kaiser M.
Publication year - 2010
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2010.07.148
Subject(s) - neural development , neuroscience , development (topology) , biology , caenorhabditis elegans , computer science , genetics , mathematics , mathematical analysis , gene
day 30 (P30), with erratic breathing, frequent apnoeas, and fatal respiratory distress at around P60 (Viemari et al, 2005). The breathing symptoms of Mecp2-/y mice are caused by earlier deficits of several neurochemical systems (Katz et al, 2009). GABA deficits which appear as early as P7 (Medhiran et al, 2008), may have a primary role in the breathing symptoms. Revisiting the breathing phenotype of young Mecp2-/y mice and analyzing the effects on breathing symptoms of midazolam, a benzodiazepine of clinical use known to potentiate the effects of endogenous GABA. Plethysmography in conscious Mecp2-/y mice was used to record breathing and analyse the changes induced by single i.p. applications of midazolam. In Mecp2-/y mice, we show that: