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[P2.08]: Transcriptional control of corticothalamic projection neuron identity by TBr1
Author(s) -
Hevner R.F.,
Bedogni F.,
Hodge R.D.,
Elsen G.E.,
Nelson B.R.,
Daza R.A.M.
Publication year - 2010
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2010.07.138
Subject(s) - library science , sociology , computer science
individuals ranging in age from 6weeks to 49years (n = 68). Additionally we measured expression of doublecortin mRNA in the DLPFC of patients with schizophrenia (n = 37) and controls (n = 37). We found a striking decline (54% in mRNA, 76% in protein) in doublecortin expression in the first year of life between neonates (<3 months) and infants (3months-1year). Doublecortin expression continued to decrease in toddler/school aged individuals then plateaued. Doublecortin expression was detectable in adults at levels ∼7% of neonates. We saw no change in doublecortin mRNA expression in the DLPFC of patients with schizophrenia. Protracted expression of doublecortin in the first years of life is consistent with the hypothesis that new neurons arrive in the cortex in postnatal life. Expression of doublecortin is maintained in adulthood which may indicate continued arrival of neurons or a further constitutive function of doublecortin. The lack of change in doublecortin in patients with schizophrenia suggests that levels of adult neuronal migration may be similar in patients compared to controls; however, further work is needed to determine if other aspects of postnatal neurogenesis are intact.