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[P2.07]: Doublecortin expression in the prefrontal cortex of developing human and in adults with schizophrenia
Author(s) -
Fung S.J.,
Sivagnanasunduram S.,
Webster M.J.,
Weickert C. Shan
Publication year - 2010
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2010.07.137
Subject(s) - schizophrenia (object oriented programming) , schizophrenia research , library science , doublecortin , citation , psychology , psychiatry , neuroscience , computer science , dentate gyrus , hippocampal formation
sion pathway genes (LRRTM2, PSD-95 and CASK) in order to begin to understand the function of gene networks underlying the emergence of early behaviours. We have generated morpholinos against NRXN-1a , NRXN1b and CNTNAP2 and injected them individually into one cell embryos and then assessed the touch and escape responses at 30 and 45 h, respectively. Knock down of either NRXN1a , NRXN1b or CNTAP2 significantly reduced the touch response at 30 hpf to a similar extent. The high penetrance of these phenotypes (71–84%) suggest that these genes are playing a major role in the development of the underlying neural circuitry responsible for this behaviour. In contrast, at 45 hpf knock down of NRXN-1a had no effect on the escape response, knock down of NRXN1b either extinguished or reduced the response, while knock down of CNTNAP2 produced an abnormal response. These very different phenotypes suggest very different roles of these synaptic adhesion network genes in the underlying neural circuitry. Our analyses are beginning to reveal the most critical genes involved in development of neural circuits underlying a simple behaviour.