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[P1.90]: MARCKS‐associated signaling complexes regulate cell polarity during progenitor proliferation and neuronal differentiation
Author(s) -
Weimer J.M.
Publication year - 2010
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2010.07.130
Subject(s) - microbiology and biotechnology , polarity (international relations) , progenitor cell , progenitor , cell polarity , biology , neuroscience , neurogenesis , cell , stem cell , genetics
Concomitant with the downregulation of BMP signaling was a substantial increase in the expression of Smad7, an inhibitor of BMP signaling, and Bambi, a negative regulator of TGF-beta signaling, upon TSA and BMP2 treatment. Despite the striking discrepancy between the overall expression profiles in TSA and BMP2 treatment, some important genes are regulated similarly, supporting a connection between chromatin reorganization and BMP signaling.