[P1.89]: Characterization of the neurogenic program activated by proneural factors in a neural stem cell model | Zendy

Drechsel D. | Zendy; Johnston C.S. | Zendy; Berninger B. | Zendy; Götz M. | Zendy; Guillemot F. | Zendy; Castro D.S. | Zendy

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[P1.89]: Characterization of the neurogenic program activated by proneural factors in a neural stem cell model

Author(s) -

Drechsel D.,

Johnston C.S.,

Berninger B.,

Götz M.,

Guillemot F.,

Castro D.S.

Publication year - 2010

Publication title -

international journal of developmental neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.761

H-Index - 88

eISSN - 1873-474X

pISSN - 0736-5748

DOI - 10.1016/j.ijdevneu.2010.07.129

Subject(s) - citation , library science , medicine , computer science

Concomitant with the downregulation of BMP signaling was a substantial increase in the expression of Smad7, an inhibitor of BMP signaling, and Bambi, a negative regulator of TGF-beta signaling, upon TSA and BMP2 treatment. Despite the striking discrepancy between the overall expression profiles in TSA and BMP2 treatment, some important genes are regulated similarly, supporting a connection between chromatin reorganization and BMP signaling.

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