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[P1.89]: Characterization of the neurogenic program activated by proneural factors in a neural stem cell model
Author(s) -
Drechsel D.,
Johnston C.S.,
Berninger B.,
Götz M.,
Guillemot F.,
Castro D.S.
Publication year - 2010
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2010.07.129
Subject(s) - citation , library science , medicine , computer science
Concomitant with the downregulation of BMP signaling was a substantial increase in the expression of Smad7, an inhibitor of BMP signaling, and Bambi, a negative regulator of TGF-beta signaling, upon TSA and BMP2 treatment. Despite the striking discrepancy between the overall expression profiles in TSA and BMP2 treatment, some important genes are regulated similarly, supporting a connection between chromatin reorganization and BMP signaling.