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[P1.87]: Two regulatory elements with opposite effects modulate the activity of prrxl1 alternative promoters
Author(s) -
Regadas I.,
Monteiro F.,
Rebelo S.,
Lima D.,
Reguenga C.
Publication year - 2010
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2010.07.127
Subject(s) - citation , library science , computer science , information retrieval
(mean fold change: 2.7) in comparison to a group of control individuals; the expression of the CDKL5 gene was similar to that of controls (mean fold change: 0.95). We are currently investigating the molecular mechanisms that lead to this de-regulation of the expression of the MECP2 gene in the absence of exonic structural changes. We propose this de-regulation of expression may underlie disease in other RTT-like patients who test negative for MECP2 mutations.