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[P1.71]: Molecular mechanisms defining the ZLI compartment include different signaling pathways
Author(s) -
MartinezFerre A.,
NavarroGarberi M.,
Martinez S.
Publication year - 2010
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2010.07.111
Subject(s) - library science , editorial board , citation , humanities , art , computer science
of ephrin-B1 is controlled by a feedback loop involving posttranscriptional regulatory mechanisms. We observed that the EfnB1 3’UTR confers instability to mRNA transcripts and we identified miR-124 as a post-transcriptional repressor of EfnB1 expression. Furthermore we showed that miR-124 is itself regulated by ephrinB1 reverse signaling, thus revealing the existence of a mutually repressive interaction between ephrin-B1 and this miRNA. Lastly, we demonstrated the relevance of this mutual inhibition for neuronal differentiation. Our results suggest that miRNAs could be important effectors of Eph/ephrin signaling to refine their domains of expression and to regulate their function.