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[P1.69]: Subcellular localization of PREP and PREPL in neuronal cells suggests functions in intracellular transport and protein secretion
Author(s) -
Morawski M.,
Schulz I.,
Rahfeld J.U.
Publication year - 2010
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2010.07.109
Subject(s) - secretion , intracellular , microbiology and biotechnology , subcellular localization , intracellular transport , protein subcellular localization prediction , transport protein , chemistry , biology , biochemistry , cytoplasm , gene
of ephrin-B1 is controlled by a feedback loop involving posttranscriptional regulatory mechanisms. We observed that the EfnB1 3’UTR confers instability to mRNA transcripts and we identified miR-124 as a post-transcriptional repressor of EfnB1 expression. Furthermore we showed that miR-124 is itself regulated by ephrinB1 reverse signaling, thus revealing the existence of a mutually repressive interaction between ephrin-B1 and this miRNA. Lastly, we demonstrated the relevance of this mutual inhibition for neuronal differentiation. Our results suggest that miRNAs could be important effectors of Eph/ephrin signaling to refine their domains of expression and to regulate their function.