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[P1.66]: Shh pathway impairment in neuronal precursor cells from the subventricular zone of the Ts65Dn mouse, an animal model for Down Syndrome
Author(s) -
Mitrugno V.M.,
Trazzi S.,
Bartesaghi R.,
Ciani E.
Publication year - 2010
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2010.07.106
Subject(s) - subventricular zone , citation , library science , computer science , biology , stem cell , microbiology and biotechnology , progenitor cell
Habituation is a form of non-associative conditioning in which there is a reduction in response to a specific stimulus presented repetitively over time. Components of the cAMP mediated signaling pathway have been previously shown to be important for normal habituation. A kinase anchoring proteins (AKAPS) are a large family of proteins originally identified in mammals which modulate the specificity of protein kinase A (PKA) function by targeting and compartmentalizing PKA to various sub-cellular structures. Rugose (rg) encodes a Drosophila A kinase anchor protein (DAKAP550) which has been previously shown to be required normal pattern formation in the developing eye (Shamloula et al 2002). We present data which show mutations in rugose(rg), which encodes a (DAKAP550) alter habituation and synaptic properties. Data from behavioral, electrophysiological and cell biological studies on the adult as well as the larval neuromuscular junction are presented here.