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[P1.54]: Quantitative and anatomical mapping of the expression of Hox genes belonging to paralog groups 1–5 in the adult central nervous system: Towards a functional analysis of Hox genes in the adult brain
Author(s) -
Theys N.,
Van Ecke A.,
DoshishtiAgolli K.,
Ahn M.T.,
Gofflot F.
Publication year - 2010
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2010.07.094
Subject(s) - hox gene , humanities , biology , philosophy , genetics , gene , gene expression
We have shown that Sox5 is expressed in neural progenitors in the spinal cord, and in a subpopulation of dorsal dI3 interneurons. Through gainand loss-of-function analyses, we found that Sox5 controls the timing of cell cycle exit in neural progenitors at the G1-S transition by counteracting the mitotic effect of the Wnt/ catenin pathway. Mechanistically, by increasing the transcriptional levels of the negative regulator Axin2, Sox5 would control the feedback repressor pathway regulating Wnt signalling. Furthermore, we have found that Sox5 downregulation in postmitotic cells is necessary for the progression of the differentiation program and that Sox5 is essential for the survival of dI3 interneurons. Hence, these data situate Sox5 as an important brake of Wnt/ -catenin mitogenic activity during the progression of neurogenesis.