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[P1.45]: Role of CD137 in regulation of neural stem cell proliferation
Author(s) -
Yun C.H.,
Lee H.M.,
Lee B.J.
Publication year - 2010
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2010.07.086
Subject(s) - citation , the republic , library science , political science , philosophy , computer science , theology
rats at PND15 and 120 compared to MS15 and control groups (MS0). However, there were no significant differences in DNMT1 and DNMT3a mRNA levels of MS15 separated animals compared to MS180 and MS0 groups at PND 15. Second, we evaluated marker genes PP1c and GR promoter area methylation patterns and transcriptional activity on PND15 and 120. We found that MS15 and MS180 are associated with DNA hypermethylation and transcriptional downregulation of the PP1c gene and demethylation and transcriptional activation of GR gene in NAc compared to control group. Further, we have a plan to correlate MS-induced epigenetic modification with addiction related behavior. Support: ETF 7585