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[P1.41]: Sprouty genes function as negative regulators of the FGF signalling pathway during cerebellar development
Author(s) -
Yu T.,
Yaguchi Y.,
Echevarria D.,
Martinez S.,
WechslerReya R.,
Basson M.A.
Publication year - 2010
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2010.07.082
Subject(s) - classics , history
spinal-projecting cells (reticular neurons) showed CR immunoreactivity, being only observed in the rhombencephalon. Some small spinal-projecting neurons showed 5-HT or TH immunoreactivity at stage 31. These serotoninergic cells were restricted to the rhombencephalon (raphe-reticular formation) while those THimmunoreactive were observed in the diencephalon (basal part of p2) and locus coeruleus (rostral rhombencephalon). Only a few serotoninergic cells give rise to spinal projections in dogfish, being proportionally less abundant than in other jawed vertebrates. No GABAergic spinal-projecting neurons were observed in the dogfish brain. Our data indicates that the adult descending supraspinal projections in dogfish develop at early embryonic stages, before of the expression of classical neurotransmitters such as GABA, dopamine and serotonin, which are thought to act as neurotrophic factors during development in other neuronal systems. Supported by the Spanish Ministry of Education and TechnologyFEDER (BFU2007-61154) and Xunta de Galicia (PGIDIT07PXIB200102PR; INCITE09ENA200048ES)