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[P1.13]: Co‐maturation of P300 component and delta band
Author(s) -
BarrigaPaulino C.I.,
Flores A.B.,
Gómez C.M.
Publication year - 2010
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2010.07.054
Subject(s) - library science , citation , computer science
matter centered at the anterior cingulate cortex were determined using LC model. Participants completed 9 subtests of the California Computerized Assessment Package (CalCAP) to assess reaction time, working-memory, and attention. Correlations between age, imaging, and cognitive measures were determined (p < 0.05 significance). The medial-orbital-frontal cortex thinned with age (r = −0.37). Improved CalCAP performance on 2 subtests (r > 0.34) and higher n-acetyl-aspartate (NAA) levels (r = −0.32) were associated with this thinning. The superior-frontal cortex also thinned with age (r = -0.45) with corresponding improved performance on 4 subtests (r > 0.33) and higher glutamate + glutamine (GLX) levels. The superior-frontal cortex volume also decreased with age (r = −0.42) and was associated with improved performance on 8 subtests (r > 0.30). Smaller volumes of the frontal pole were observed in older participants (r = −0.31), which correlated with improved performance on 1 test (r = 0.31). Smaller volumes in the medialorbital-frontal cortex correlated with improved performance on 4 subtests (r > 0.35) and higher NAA levels (r = −0.31). These results emphasize that the frontal cortex is still developing into the 3rd decade of life. In addition, our data suggest that cortical pruning (thinning and volume reductions) during periadolescent brain development is associated with increasing concentrations of neuronal markers (NAA and GLX), and improved performance on higher cognitive functions, possibly due to more compact and efficient neuronal function and enhanced neuronal integrity.