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Role of brominated diphenly ether‐209 in the differentiation of neural stem cells in vitro
Author(s) -
Zhang Chunfang,
Liu Xianbao,
Chen Dunjin
Publication year - 2010
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2010.06.002
Subject(s) - neural stem cell , neurosphere , neurite , in vitro , chemistry , microbiology and biotechnology , stem cell , ether , biology , biochemistry , adult stem cell , organic chemistry , endothelial stem cell
Brominated diphenly ether‐209 (BDE‐209, decaBDE) is among the most common flame retardants. In a previous study, it was confirmed that exposure to BDE‐209 can decrease learning and memory in mice. However, it is still unknown whether BDE‐209 has an effect on cultured neural stem cells (NSCs). To analyse the role of BDE‐209 in the differentiation of neural stem cells, NSCs obtained from neonatal rats were cultured as neurospheres in DMEM/F12 medium that contained different concentrations of BDE‐209 for 7 days. BDE‐209 was found to inhibit neurite outgrowth and the differentiation of NSCs into neurons in a concentration‐dependent manner. BDE‐209 also enhanced the ratio of differentiation of NSCs into glial cells.