Premium
The cochlea in fetuses with neural tube defects
Author(s) -
Schmutzhard Joachim,
Glueckert Rudolf,
Bitsche Mario,
Abraham Irene,
Falkeis Christina,
Schwentner Ilona,
Riechelmann Herbert,
Müller Bert,
Beckmann Felix,
Sergi Consolato,
SchrottFischer Annelies
Publication year - 2009
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2009.07.008
Subject(s) - neural tube , anatomy , cochlea , anencephaly , spina bifida , temporal bone , biology , pathology , neural tube defect , inner ear , medicine , embryo , microbiology and biotechnology , genetics
In this study different malformations of the cochlea could be demonstrated. Nevertheless, we could not delineate a distinct malformation of the inner ear, that can be linked to a neural tube defect. Neural tube defects are a frequent and heterogeneous group of malformations, ranging from the survivable spina bifida to fatal anencephaly. In multiple animal models an involvement of the vestibulocochlear system has been demonstrated. In this article human fetal temporal bones of neural tube defects were analysed in a multimodular work‐up. The morphologic study was performed with light microscopy, transmission electron microscopy and synchrotron radiation‐based microcomputed tomography. Immunohistochemistry for different neuronal markers such as peripherin, beta‐III‐tubulin and vimentin helped to evaluate ontogenetic tissue development. Eight fetal temporal bones with neural tube defects and five control temporal bones were included into the morphologic study. The morphologic results of the neural tube defect temporal bones showed six regularly developed cochleas and two with only a single cochlear turn. Three of the neural tube defect temporal bones were further examined with immunohistochemical analysis. No differences in the staining pattern for peripherin, beta‐III‐tubulin and vimentin were detected.