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[P2.74]: Acupuncture improves cognitive deficits, regulates the brain cell proliferation and migration of SAMP8 mice
Author(s) -
Yu J.C.,
Cheng H.Y.,
Han J.X.
Publication year - 2008
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2008.09.199
Subject(s) - traditional chinese medicine , acupuncture , citation , cognition , medicine , psychology , library science , traditional medicine , alternative medicine , neuroscience , computer science , pathology
Senescence-acceleratedmouse prone 8 (SAMP8) is an autogenic senile strain characterized by early cognitive impairment and age-related deterioration of learning andmemory. This study is to investigate the effect of acupuncture on behavioral changes and brain cell events (proliferation and migration) of SAMP8. Methods: Male 4-month-old SAMP8 and age-matched homologous normal aging SAMR1 mice were divided into four groups: SAMP8 acupuncture group (Pa), SAMP8 non-acupoint control group (Pn), SAMP8 control group (Pc) and SAMR1 normal control group (Rc). The cognitive function of SAMP8 was tested by using Morris watermaze. The brain cell proliferation andmigrationwere revealed by 5-bromo-2-deoxyuridine (BrdU) specific immunodetection. Results: The cognitive deficit of SAMP8 was revealed and significantly improved by ‘‘Yiqitiaoxue and Fubenpeiyuan’’ acupuncture method. Meanwhile, the decreased cell proliferation in dentate gyrus (DG) of SAMP8 was greatly enhanced by the therapeutic acupuncture, suggesting acupoint-related specificity. Even though no significant differences were found in ventricular/ subventricular zones (VZ/SVZ) of the third ventricle (V3) and lateral ventricle (LV) between groups, we obtained interesting results: a stream-like distribution of newly proliferated cells presented along the dorsum of alveus hippocampi (Alv), extending from LV to corpus callosum (CC), and the therapeutic acupuncture showed a marked effect on this region, which probably indicating the migration of proliferated brain cells. Discussion: Our research suggests that acupuncture could induce different cell proliferation in different brain regions of SAMP8, as well as the migration of proliferated cells, which brings forth the need to explore further for the mechanism of cognitive deficits and acupuncture intervention in this field.