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[P2.45]: Endoglycan plays a role in axon guidance and neuronal migration by downregulating cell–cell adhesion
Author(s) -
Baeriswyl T.,
Stoeckli E.T.
Publication year - 2008
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2008.09.170
Subject(s) - citation , library science , axon guidance , axon , neuroscience , cognitive science , psychology , computer science
movementwasexamined. Treating explantsacutelywithpicrotoxin, a GABAA receptor antagonist, significantly increased GnRH-1 neuronal migration [even at 4 days = 23mm/h]. Muscimol, a GABAA receptor agonist, attenuated GnRH-1 neuronal migration at all days examined (10mm/h) and GnRH-1 neuronal speed in nasal explants from GAD67 KO mice was significantly faster as compared to controls. This study reports new aspects of GnRH-1 neuronal migration such as speed, GABA influence and saltatory movement. These data indicate that GnRH-1 cells, which undergo neurophilic migration, share characteristic with other migratory neurons like cerebellar and cortical neurons, which undergo gliophilic migration. Moreover this study describes a model in which large numbers of primaryneuronscanberesolved, apposed to theirnativepathway, to evaluate specific molecules important for cell migration as well as changes in cellular components during movement.