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[P2.40]: A requirement for the forkhead protein foxp1 and hox proteins in the columnar organization of spinal motor neurons
Author(s) -
Rousso D.L.,
Gaber Z.B.,
Li S.,
Wellik D.,
Morrisey E.E.,
Novitch B.G.
Publication year - 2008
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2008.09.165
Subject(s) - library science , hox gene , citation , biology , computer science , genetics , gene , transcription factor
cyclin EmRNA level, increased cyclin/CDKactivitymight account for the increased cell proliferation. To characterize effects on cortex structure, we performed stereological analysis at E18.5 and found a 15% increase in total volumeand26% increase in total cells.Whileno change in cell density was observed, the depth of layers I and VIwas increased (39% and 19%, respectively). Furthermore, using the layer VI specific marker Tbr1, we found a 40% increase in the mutants at E18.5 and a 2-fold increase in protein by western blotting. Our observations suggest that p57 is a critical regulator of cortical precursor proliferation, andmay be determinant of laminar-specific cell production during cortical neurogenesis.