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[P1.60]: Protective role of BDNF in amyloid‐β‐induced neurodegeneration of presynaptic axon arbors: in vivo imaging studies
Author(s) -
Meynard M.M.,
Hu B.,
Wu J.,
Glabe C.G.,
CohenCory S.
Publication year - 2008
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2008.09.110
Subject(s) - neuroscience , library science , citation , neurodegeneration , cognitive science , psychology , medicine , computer science , pathology , disease
merase chain reaction, and electrophysiological recording. Compared with the control group, the number of synaptic puncta significantly increased (P < 0.01) as showing by immunostaining or RT-PCR. The spontaneous synaptic currents (SSCs) on SCGNs were also remarkably increased (P < 0.01). Additionally, the SSCs could be blocked by the specific nicotinic receptors blocker, but not by the glutamate receptor antagonist. These observations clearly demonstrated the increased and functional synapses in the coculture system, strongly suggesting novel ‘‘hybrid’’ synaptogenesis formed between the somatic neurons and the automatic neurons; acetylcholine and nicotinic receptor may play pivotal roles in mediating these processes.