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[P1.59]: Antibodies against the amphiphysin sh‐3 domain mediate reduced gabaergic motor inhibition and anxiety of stiff person syndrome
Author(s) -
Geis C.,
Weishaupt A.,
Hallermann S.,
Toyka K.,
Heckmann M.,
Sommer C.
Publication year - 2008
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2008.09.109
Subject(s) - citation , medicine , computer science , library science
merase chain reaction, and electrophysiological recording. Compared with the control group, the number of synaptic puncta significantly increased (P < 0.01) as showing by immunostaining or RT-PCR. The spontaneous synaptic currents (SSCs) on SCGNs were also remarkably increased (P < 0.01). Additionally, the SSCs could be blocked by the specific nicotinic receptors blocker, but not by the glutamate receptor antagonist. These observations clearly demonstrated the increased and functional synapses in the coculture system, strongly suggesting novel ‘‘hybrid’’ synaptogenesis formed between the somatic neurons and the automatic neurons; acetylcholine and nicotinic receptor may play pivotal roles in mediating these processes.