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[P1.46]: Patterning important for guiding developing axons must be maintained by signalling molecules
Author(s) -
AtkinsonLeadbeater K.,
Hehr C.,
Retaux S.,
McFarlane S.
Publication year - 2008
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2008.09.096
Subject(s) - citation , library science , sociology , psychology , computer science , world wide web
Themammillary body (MB) comprises several nuclei lying at the posterior end of the hypothalamus that have been implicated in spatial memory function. The MB receives hippocampal input and projects to the thalamus and tegmentum, thus linking together forebrain and midbrain areas. Here we show that the LIM-HD transcription factor Lhx5 is expressed in theMBprimordiumearly in mouse embryogenesis. Targeted inactivation of Lhx5 results in a dramatic reductionofMBareaandaconcomitantabsenceof efferent projections perinatally. The early specification of the MB area appeared severely altered, as shown by the lack of expression of Foxb1, Sim2, and other novel MB markers by in situ hybridization. Interestingly, Lhx5 / embryos expressed Lhx2 and Lhx9 ectopically in this area, suggesting an intricate regulation of gene expression between LIM-HDmembers during mammillary body development.