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[P1.11]: Stress in neonates changes plasticity in adult hippocampo‐amygdalar neural circuits
Author(s) -
Blaise J.H.
Publication year - 2008
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2008.09.061
Subject(s) - citation , neuroscience , neuroplasticity , library science , psychology , computer science , cognitive science , gerontology , medicine
radial glia remains the same whereas the number of EGFP oligodendrocytes increases over time. Based on work in Drosophila melanogaster, we hypothesized that asymmetrically localized factors direct divisions of EGFP radial glia that give rise to new radial glial precursors and oligodendrocytes. To test this we used an antibody against atypical Protein Kinase C (aPKC) to label sections of the zebrafish spinal cord. We found that aPKC is asymmetrically localized to the apical membrane of EGFP radial glia. Notably, heart and soul mutant larvae, which express a truncated and kinase deficient form of aPKCl, have a deficit of EGFP radial glial precursors but excess oligodendrocyte progenitor cells. One possible explanation for this result is that, in the absence of polarity cues, EGFP radial glia divide symmetrically, producing only oligodendrocytes and depleting the precursor population.