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[P1.08]: The role of cell polarity in specifying and maintaining adult zebrafish spinal cord precursors
Author(s) -
Roberts R.K.,
Park HC.,
Appel B.
Publication year - 2008
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2008.09.058
Subject(s) - citation , library science , zebrafish , computer science , cognitive science , psychology , biology , biochemistry , gene
Tiam1 gene. These SNPs are rs7280029, rs8131958, rs2833423, and rs8133912 and had p-values of 0.03, 0.04, 0.03, and 0.05 respectively, corrected for multiple testing. Haplotype analysis within Cdc42 showed suggestive results for three overtransmitted two-SNP haplotypes: CT (rs2056974-rs10917145), CT (rs2056975rs2056974), and GT (rs10917145-rs2268177) with nominal pvalues of 0.003, 0.002, and 0.002 respectively. Our results suggest that Tiam1, a critical mediator of NMDA receptors and Cdc42, an actin cytoskeletal regulator, may be implicated in the etiology of autism.