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Animal models of neonatal stroke and response to erythropoietin and cardiotrophin‐1
Author(s) -
Sola Augusto,
Peng Hui,
Rogido Marta,
Wen TongChun
Publication year - 2008
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2007.08.016
Subject(s) - stroke (engine) , neuroprotection , medicine , erythropoietin , incidence (geometry) , intensive care medicine , pediatrics , mechanical engineering , physics , optics , engineering
Neonatal stroke is increasingly recognized in preterm and term infants, and the rate of arterial ischemic infarction occurring around the time of birth is as high as the annual incidence of large‐vessel ischemic stroke in adults. Thus, neonatal stroke is a major contributor to perinatal morbidity and mortality, and a considerable number of these children will develop long‐term neurodevelopmental disabilities. Our ability to investigate this situation has been limited by the technical challenges in developing suitable animal models. Our objective is to describe recent evidence in relation to animal models of neonatal stroke. In addition, we review and report potential neuroprotective strategies specific to neonatal stroke, with a focus on erythropoietin and cardiotrophin‐1 because of their potential role in protection as well as repair.