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[P249]: Class III semaphorin signaling is required for differential target recognition by the left and right habenular nuclei of the zebrafish brain
Author(s) -
Kuan Y.S.,
Yu H.H.,
Moens C.B.,
Halpern M.E.
Publication year - 2006
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2006.09.307
Subject(s) - library science , institution , embryology , center (category theory) , biology , philosophy , classics , political science , genetics , history , law , computer science , chemistry , crystallography
all, pioneer axon guidance effects of SLT-1 acting through the SAX-3/Robo receptor, but does not appear to be involved in SLT1-independent signaling by SAX-3/Robo. The more restricted set of axons affected by eva-1 and slt-1 mutations compared to sax-3 mutations and the more limited expression of EVA-1 compared to SAX-3, suggests that in neurons expressing EVA-1 and SAX-3 (e.g., AVM) EVA-1 causes SAX-3 to respond to SLT-1 as a guidance cue. Consistent with this, genetic mosaic analysis and rescue of AVM guidance defects by cell-specific expression indicate that EVA-1, like SAX-3, acts in AVM to perform its guidance functions.