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[P233]: A link between Foxg1 and Zic2 in the control of retinal axon divergence
Author(s) -
Tian N.,
Pratt T.,
Price D.
Publication year - 2006
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2006.09.293
Subject(s) - citation , tian , library science , sociology , history , computer science , ancient history
was obvious in the optic stalk and optic tract, but not in the chiasm. The downregulation of NgR at the chiasm was supported by in vitro assays showing significant reduction of receptor expression in dorsal nasal but not ventral temporal growth cones when they encounter the chiasm. Blocking NgR function with peptide antagonist in brain slice culture of the pathway produced significant reduction in the uncrossed projection, but had no effect on axon crossing at the midline. Similar abnormality was observed in slices treated with Nogo blocking antibody. These results provide evidences that interaction of Nogo and its receptor is important for patterning the axon divergence in the mouse optic pathway.