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[P220]: Distribution of VIP and VIP receptor in chicken ovary during development
Author(s) -
GonzálezdelPliego M.,
AguirreBenítez E.,
VelázquezCarranza A.,
SolanoAgama C.,
MendozaGarrido M.E
Publication year - 2006
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2006.09.280
Subject(s) - humanities , art
The homeodomain factor Lbx1 is expressed in postmitotic neurons in the ventral alar plate of the developing hindbrain extending from rhombomere 2 to the caudal medulla. It has been shown that Lbx1 distinguishes two major programs of neuronal differentiation in the dorsal spinal cord (class A, Lbx− and class B, Lbx+). Here, we introduce a classification of the neuronal subtypes emerging in the alar plate of the hindbrain according to their transcription factor profiles. Lineage tracing allowed us to define derivatives of Lbx+ neurons, which include the spinal trigeminal nucleus and GABAergic neurons in the nucleus of solitary tract. The nucleus of the solitary tract is a major brainstem relay station for visceral sensory input and modulates the frequency of breathing and cardiac contraction, whereas the spinal trigeminal nucleus receives somatosensory input. The loss of Lbx1 leads to an abnormal molecular identity and to a mis-specification of neurons participating in the formation of these sensory relay centers. In Lbx1 mutant mice the spinal trigeminal nucleus is greatly reduced or lost and the nucleus of solitary tract is enlarged and exhibits an abberant neuronal circuitry. This is accompanied by long periods of apnea and a reduced frequency of cardiac contraction. Lbx1 is therefore an important determinant in the specification of hindbrain neurons that process sensory information.