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[P197]: LIMK1 in Xenopus retinal development
Author(s) -
Hocking J.,
McFarlane S.,
Funakoshi H.,
Nakamura T.
Publication year - 2006
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2006.09.257
Subject(s) - library science , citation , sociology , ophthalmology , medicine , computer science
of brain cell death in a rat pup model of hypoxia/ischemia and hyperoxic resuscitation. Methods: Ischemia is induced by cauterization of the left common carotid artery followed by 90 min of hypoxia (7.8% O2 in nitrogen) and 2 h of hyperoxia (>95% O2) in 7 d rat pups. These pups are then treated with subcutaneous homocysteine (75 nmol/kg), for 2 d and then sacrificed. Brains were collected for determination of sulfur containing amino acids and apoptosis in frontal cortex and cerebellum. Results: Increased cell death was found in those animals treated with homocysteine. Discussion: The implication of this finding is that preterm infants subjected to hypoxia stress at birth followed by hyperoxic resuscitation may be at increased risk for brain injury if they have increased amounts of homocysteine, possibly due to poor maternal folic acid status. This confluence of events may be an explanatory mechanism for the cognitive deficits observed in such infants.