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[P192]: The p75 neurotrophin receptor regulates activity‐dependent axon competition by antagonizing TrkA‐mediated Ras–Raf–MAPK signaling
Author(s) -
Singh K.,
Kramer B.,
Lin D.,
Aloyz R.,
Kaplan D.,
Miller F.
Publication year - 2006
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2006.09.252
Subject(s) - sick child , miller , medicine , general hospital , mapk/erk pathway , psychology , pediatrics , signal transduction , genetics , biology , ecology
PCNA in cells leaving the cell cycle decrease only about 30% within 24 h (Bravo and Macdonald-Bravo, 1987). Thus, weak Pax6/PCNAir periventricular cells could represent early postmitotic cells. The distribution of the periventricular intense Pax6ir cells in relation with some forebrain boundaries (alar-basal and diencephalon–mesencephalon boundaries, see abstract of Ferreiro-Galve et al.) is compatible with a role of Pax6 in the forebrain patterning. Moreover, the mediolateral distribution of Pax6ir cells could correspond with migratory streams related with axon guidance. In addition, in the forebrain of shark embryos (and juveniles) we have evidenced some Pax6ir cells also immunoreactive to TH or to GAD that represent differentiating neurons (Fig. 2).