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[P182]: Use of a β‐galactosidase reporter reveals novel areas of Disabled‐1 expression in embryonic and postnatal mouse CNS
Author(s) -
Carpenter E.,
Hu Y.H.,
Yap T.,
Han J.,
Pramatarova A.,
Howell B.,
Phelps P.
Publication year - 2006
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2006.09.242
Subject(s) - embryonic stem cell , citation , library science , biology , medicine , genetics , computer science , gene
out the Dab1 and scrambler spinal cords but not in the Vldlr−/− and ApoER2−/− mice. Dab1 and scrambler mutants, but not the Vldlr−/− and ApoER2−/− mice or controls, also contained NK-1-positive neurons in lamina II, an area normally devoid of these neurons. We conclude that the established Reelin signaling pathway contributes to neuronal positioning within the superficial dorsal horn and LSN and that deletion of the first or the third component of the pathway significantly alters both thermal and mechanical nociceptive processing.