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[P161]: Role of BDNF in early gustatory neuron development
Author(s) -
Harlow D.,
Barlow L.
Publication year - 2006
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2006.09.221
Subject(s) - library science , citation , center (category theory) , health science , psychology , cognitive science , sociology , gerontology , medicine , computer science , medical education , chemistry , crystallography
found that PMA and PKC induced a large increase in Notch expression and that the PKC S729A mutant abolished the PMA effect. To examine the role of Notch1 in PMA and PKC effects, we employed the -secretase inhibitor L-685,458. Treatment of the cells with L-685,458 decreased the number of GFAP+ cells whereas it increased the number of -tubulinIII+ cells. Moreover, L-685,458 abolished the effect of PMA on the generation of astrocytes. Our data suggest an important role of PKC in astrocytic differentiation and implicate Notch1 as a possible mediator of this effect.