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[P159]: PKCɛ induces astrogenesis in multipotential neural precursor cells
Author(s) -
Steinhart R.,
Kazimirsky G.,
Okhrimenko H.,
BenHur T.,
Brodie C.
Publication year - 2006
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2006.09.219
Subject(s) - hebrew , citation , library science , humanities , history , computer science , philosophy , classics
that only a subset of ZII− Purkinje cells are ectopic in cdf and taken together this indicates that there are at least two classes of ZII− Purkinje cells. Interestingly, recent experiments examining the origins of ZII− cells during development also suggest that at least two immunologically distinct populations of Purkinje cells contribute to the ZII− population in the adult cerebellum one that expresses neurogranin alone (NG+) and a second that expresses a combination of heat shock protein25, calbindin and neurogranin (HSP25+). Our data reveals that both Purkinje cell phenotypes are present in the cdf cerebellum. However, we observed that the overwhelming majority of ectopic Purkinje cells in the perinatal cdf cerebellum are represented by the HSP25+ subset. This observation supports the adult data because a population of cells predicted to contribute to the adult ZII− population is ectopic in the perinatal cerebellum. Finally, despite the ectopia present in the cdf cerebellum, overall, parasagittal patterning is very similar to wild type. Thus, our evidence indicates that mediolateral patterning is established prior to Purkinje cell dispersal and that this dispersal process is differentially regulated across Purkinje cell subclasses.