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[P148]: Fork head/winged helix transcription factors, Foxa1 and Foxa2, are essential regulators of midbrain dopaminergic differentiation
Author(s) -
Ang S.L,
Ferri A.,
Yan C.,
Mavromatakis Y.,
Kaestner K.,
Kageyama R.
Publication year - 2006
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2006.09.209
Subject(s) - foxa2 , transcription factor , biology , genetics , gene
ous studies, Pea3 and Erm – transcription factors, targets of Fgf signaling – were clearly downregulated or were completely missing in mid-hindbrain boundary in Fgfr1 mutants (Trokovic et al., 2005). However, their expression was remaining further away of the boundary. Fgfr2 and Fgfr3 are expressed in the anterior part of the midbrain and the posterior part of rhombomere 1 in the hindbrain, but not in the mid-hindbrain boundary. The expression decreases towards the boundary. To study functions of Fgfr2 and Fgfr3, I have combined different variations of Fgfr1, Fgfr2 and Fgfr3 mutant alleles. To avoid early lethality, conditional alleles of Fgfr1 and Fgfr2 are used. Here, we show that Fgfr1, Fgfr2 and Fgfr3 have redundant roles in the development of midbrain and rhombomere 1. We have combined different variations of Fgfr1, Fgfr2 and Fgfr3 mutant alleles. Fgfr1-Fgfr2 double and Fgfr1–Fgfr2–Fgfr3 triple mutants show defects in cell survival, patterning and neuronal differentiation in the midbrain and rhombomere 1.