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[P139]: Pax6 prevents premature progenitor cell differentiation, promotes the development of basal progenitors and cell‐autonomously represses ventral identities in the developing neocortex
Author(s) -
Quinn J.,
Molinek M.,
Martynoga B.,
Zaki P.,
Hevner R.,
West J.,
Price D.
Publication year - 2006
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2006.09.201
Subject(s) - progenitor cell , biology , progenitor , citation , library science , stem cell , genetics , computer science
rescued in Shh;Gli3 double mutants. We reasoned that, if Foxg1 exerts its effects on ventral telencephalon through participation in Shh-mediated antagonism of Gli3 activity, then ventral defects in Foxg1 mutants should be rescued when Gli3 activity is removed. We therefore generated Foxg1;Gli3 double mutant embryos. These showed a partial rescue of the Foxg1 mutant phenotype, in that expression of several ventral markers was restored. This suggests that Foxg1 does indeed participate in Shh-mediated antagonism of Gli3 activity. However, Foxg1;Gli3 telencephalon still exhibits several D/V patterning defects, consistent with further, Hh-independent, roles for Foxg1 in telencephalic patterning. These findings show that Foxg1 plays a central and multi-functional role in the development of the ventral telencephalon and its derivatives.