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[P101]: Apolipoprotein E, angiotensin‐converting enzyme and kallikrein gene polymorphisms and the risk of Alzheimer's disease and vascular dementia
Author(s) -
Wang H.K.,
Chen C.M.,
Fung H.C.,
Hsu W.C.,
LeeChen G.J.
Publication year - 2006
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2006.09.163
Subject(s) - apolipoprotein e , vascular dementia , library science , medicine , gerontology , dementia , disease , computer science
cells transfected with expanded TBP revealed reduced oxidative tolerance upon t-butylhydroperoxide treatment. The reduced oxidative stress tolerance was also observed using lymphoblastoid cell lines from SCA17 patients. Proteomics analysis on transiently transfected 293 and lymphoblastoid cells with TBP expansion further suggests the involvement of proteins assisting folding and metabolism on the disease pathogenesis. The identified abnormalities in neurodegeneration may be used as a “biomarker” for assessing the efficacy of potential therapeutic strategies for SCAs and other polyglutamine diseases.